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Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery
Product Name MC-Val-Cit-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C71H95FN10O21 Molecular Weight 1443
S)-AHPC-CO-C4-alkyne Synonyms CAS Number 2374122-28-6 Related CAS Molecular Formula C29H38N4O4S Molecular Weight 538
Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:10mg no extreme temperatures or solventsSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a
