DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE deuterium-labeled-amine SJ6986 has very good oral

SJ6986 has very good oral bioavailability (F = 84% in mice)

Mallareddy

Product Name CA-amide-PEG3-Biotin Synonyms biotin Halotag Ligand PEG3 CAS Number N/A Related CAS N/A Molecular Formula C29H53ClN4O8S Molecular Weight 653

364 SMILES OCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE deuterium-labeled-amine SJ6986 has very good oralSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further