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Product Name Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C83H133N11O24 Molecular Weight 1669
which reacts with benzylguanine (BG)or chloropyrimidine (CP) derivatives
Product Name Thalidomide-O-C3-acid Synonyms Thalidomide-4'-O-C3-acid CAS Number 2169266-64-0 Related CAS Molecular Formula C17H16N2O7 Molecular Weight 360
Product Name DOTA-heptyne Synonyms CAS Number n/a Related CAS Molecular Formula C23H39N5O7 Molecular Weight 497
Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-Exatecan Size:25mg Product Name Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,
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