DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:25mg 4 SMILES FC(F)(F)OC1=C(C=CC=C1)S(=O)(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Purity (HPLC)

4 SMILES FC(F)(F)OC1=C(C=CC=C1)S(=O)(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Product Name Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C42H66N6O16 Molecular Weight 911

with a Kd value of 69 nM towards DCAF1 measured by fluorescence polarization

Product Name Pomalidomide-CO-C3-Br Synonyms Pomalidomide-4'-CO-C3-Br CAS Number 2227423-26-7 Related CAS Molecular Formula C17H16BrN3O5 Molecular Weight 422

DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:25mg 4 SMILES FC(F)(F)OC1=C(C=CC=C1)S(=O)(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further